Malignant lymphoma clinical performance

Posted by MOMOLI on July 9, 2008 in Cancer

In the lesion and the scope of the different variety of clinical manifestations of lymphoma. Primary lesion is found in lymph nodes, but also can be found in lymph nodes outside the organ, such as tonsils, nasopharyngeal, gastrointestinal tract, spleen, bones and skin, etc., a guitar, particularly multiple lesions in the non-Dr Lin. Mode of transmission of disease from primary site and adjacent lymph nodes were communicators such as Hodgkin’s disease, have crossed the nearby lymph nodes and distant to the communicators, commonly found in non-Hodgkin’s lymphoma.

Non-Hodgkin’s lymphoma can also multi-center origin, the disease often have general early disseminated. Lymphoma can only single group with swollen lymph nodes without systemic symptoms, can also be no superficial lymph nodes and a general invasion, and with the corresponding signs and symptoms. Hodgkin’s disease often superficial lymphadenopathy-led see symptoms, the primary organ outside the lymph nodes, only 9 percent, instead of the original Hodgkin’s lymphoma in the lymph nodes outside to see more, into a lot of leukemia.

(A) symptoms
Malignant lymphoma symptoms of systemic and which types of diseases because of the different periods and different Jiaoxi  bran only cheek Li Shang Yi Chu S  Peten ⒆ brother ⒆ Cou card Court ⑷ from ⑾  ㄌ Jin Lu Dianshan «0% or more) , Night sweats and other more common, followed by a anorexia, easy fatigue, itching, and so on. Systemic symptoms and age of onset, the scope of cancer, immunity and so on. Elderly patients, immune function or poor focal onset, systemic symptoms significantly. No systemic symptoms, their survival rate than those with symptoms three times larger.

1, fever
Heat Multi-irregular, with sustained high fever, can also be intermittent low heat, a handful of hot cycle, which met in the 1 / 6 of Hodgkin’s disease. Early fever, Hodgkin’s disease accounts for about 30 percent to 50 percent, but non-Hodgkin’s leaching Nengshangnengxia general of the disease than when the pan-fever. Heat retire at the Dafa Lin Chun-based disease characteristics may be.

2, pruritus
This is a Hodgkin’s disease-specific performance. Focal itching lesions occurred in the regional Department of lymphatic drainage, body itching mostly occurred in the abdomen or a mediastinal disease cases.

3, alcohol pain
About 17% to 20% of Hodgkin’s disease, in 20 minutes after drinking, local lesions in pain. Its symptoms can be as early as in other symptoms and X-ray, has a diagnosis of. When the disease remission, alcohol pain that will disappear, when the recurrence of return. Alcohol pain of unknown.

4, small lesions, the symptoms
1), gastrointestinal Foreign 1,246 cases of lymphoma cases shows that the lymph nodes outside the lymphoid tissue lymphoma occurred in most of gastrointestinal diseases in non-Hodgkin’s lymphoma accounted for 13% to 25%, Hodgkin’s disease Only 2 percent. Fresh clinical performance meritocratic to subside, abdominal pain, diarrhea, abdominal mass, obstruction and bleeding. Emplacement and parts to the small intestine, which more than half of the ileum, followed by stomach, colon rarely involved. Primary intestinal tumor in non-Hodgkin’s lymphoma up to see, can absorb adverse syndrome or fat diarrhoea as the main clinical performance, disease occurred in the jejunum. Gastrointestinal diseases in general through the lymphatic mesenteric, retroperitoneal lymph node spread from.
2), liver and gallbladder liver involvement may be cited straight liver pain. Intrahepatic diffuse infiltration pressure or swollen lymph nodes detect common bile duct, jaundice may occur. Hodgkin’s disease involving the liver to about 15% of jaundice.
3), a partial skeleton clinical manifestations of secondary bone pain and pressure detection of symptoms.
4), non-specific damage to the skin of a common skin disease and itching Prurigo. Pruritus in Hodgkin’s disease more(85 per cent), ahead of the other rash and there. Khan also severely autistic even see.
5), tonsils and mouth, nose and throat mouth of lymphoma, nasopharyngeal, clinical swallowing difficult, stuffy nose, epistaxis.
6), other lymphoma can still infiltrating the pancreas, a malabsorption syndrome. Mediastinal sprinkling of transfer to the Palestinian pericardium, can cause localized tumor. Invasive breast, thyroid, the lacrimal gland, bladder, testicular and ovarian, and other corresponding symptom and cause are very rare.

(B) signs:
As lesions and scope of different, the signs of lymphoma variety of performance. Primary lesion is found in lymph nodes also can be found in lymph nodes outside the organ, such as tonsils, nasopharynx, the Ministry of gastrointestinal, spleen, bones and skin, etc., a guitar, particularly multiple lesions in non-Hodgkin’s lymphoma. Mode of transmission of disease from primary site to nearby lymph nodes were communicators such as Hodgkin’s disease, have crossed the nearby lymph nodes and distant to the communicators, commonly found in non-Hodgkin’s lymphoma. Non-Hodgkin’s lymphoma can be multi-center politicians origin, the disease often have general early disseminated. Lymphoma can only single group with swollen lymph nodes without systemic symptoms, can also be no superficial lymph nodes and a general invasion, and with the corresponding signs and symptoms. Hodgkin’s disease often superficial lymphadenopathy-led see signs, the original guitar Deng Lin in the tissues and organs other than those only 9 percent, instead of the original Hodgkin’s lymphoma in the lymph nodes outside to see more, into a lot of leukemia.

1, swollen lymph nodes
Lymphadenopathy-based disease characteristics. Superficial lymph nodes painless, progressive enlargement is often the first performance, particularly in the neck for lymph nodes Most of followed by the armpits and groin in the first on the block or less. Hodgkin’s disease in the first opera to lymph nodes, 60% to 70%, left more than right. Supraclavicular lymph nodes have been disseminated lesions tips, right from the mediastinum or Liangfei, often from the left retroperitoneal. The activities can be swollen lymph nodes, bone-like feeling; course at any time-Chin, a large and small around the leaching Nengshangnengxia node swelling, and integration into a massive corporation. If the lymph nodes increased rapidly, and even violations of the nerve can cause pain. A small number of patients are believed to be superficial without deep swollen lymph nodes. Non-Hodgkin’s lymphoma to throwing Bajie onset swollen to 56 per cent, half occurred in the neck, but more involved oropharyngeal Central, mesenteric and groin. Mediastinal lymph nodes more common in Hodgkin disease, especially in young patients (tuberous sclerosis are often bilateral swelling), to diffuse lymph nodes found in cough caused the lymphoma; are relatively poor prognosis. Deep lymph nodes can cause symptoms of oppression, such as the lymph node swelling caused coughing, chest tightness, shortness of breath, atelectasis, cervical sympathetic paralysis syndrome, the superior vena cava oppression levy; hilar lymph nodes, oppression from the common bile duct Jaundice and hepatomegaly; retroperitoneal onto Bajie in the swelling, can cause back pain and lower extremities, the perineum or scrotum edema, oppression ureter and kidney caused water in Bangladesh. Deep lymph node involvement, clinical often fever as the main performance.

2, a guitar, the signs of disease
1), liver and spleen involvement can cause liver enlargement, the biopsy about 25% to 50% of non-Hodgkin’s lymphoma with liver involvement, particularly more common in follicular or diffuse small cleaved cell non-Hodgkin’s lymphatic Tumor. Most of the spleen infiltration by Ma Lin abdominal lymph node of the lesions from the spread. Hodgkin’s disease early splenomegaly not uncommon, but with the course of progress and more generally about 10 percent. Hodgkin’s disease, splenomegaly by pathological examination, only 32 percent have lesions, that the degree of spleen involvement is not consistent with clinical findings. Splenomegaly found in 30 percent to 40 percent early adult non-Hodgkin’s lymphoma. Hodgkin’s disease of the liver changed from the spleen from disseminated through the portal, a liver disease, have been involved spleen, patients with poor prognosis.

2), chest in the 100-Hodgkin’s lymph, about 25 percent in the course of disease occurred in the chest and fluid, with the exception of tumor-infiltrating, may also be due to mediastinal involvement, lymphatic resistance caused by the cold.

3), bone malignant lymphoma have partial skeleton of the tenderness, pathological fracture. Hodgkin’s disease involving bone, or 10% to 35%, non-Hodgkin’s lymphoma more to the thoracic and lumbar most commonly involved, a thighbone, ribs, pelvis and skull head followed by more blood from the broadcast ingot Since the casual or near the soft tissue infiltration by the tumor. X-ray showed that the ivory of the spine (ivory vertebra) or osteolytic changes. About 4 diffuse large-cell or cell non-Hodgkin’s lymphoma, even in the bone can be the primary organization; younger patients. I long bones, mainly osteolytic changes, the nucleus of the lesions on the radiation-sensitive, there are certain clinical significance.

4), skin-specific skin damage more common in adult T-cell leukemia / lymphoma syndrome or mycosis fungoides, the performance of diversification, including mass, subcutaneous nodules, invasive plaque, ulcers, papules, often seen at first Head and neck. With herpes or customs of the Hodgkin’s disease, accounting for 5 percent to 16 percent. Ichthyosis, the stripping of dual red disease can also see. Lymphoma is involved skin, often prompted to have access to advanced disease and blood spread. But a few of the original skin of Hodgkin’s disease and mycosis fungoides, can be long-term survival.

5), tonsils and mouth, nose and throat lymphoma violations of mouth, nose and pharynx, 96 percent to diffuse the original cell and tissue cell non-Hodgkin’s lymphoma, occurred in most parts soft palate, tonsils, followed by For nasal and sinus, nasopharyngeal and tongue less. Local mass of visible and lower jaw swollen lymph nodes.

6), kidney 696 cases of malignant lymphoma in the autopsy, renal infiltration of 33.5 percent, have reported up to 60 percent; for non-Hodgkin’s lymphoma, Hodgkin’s disease only 13%. Lesions often side, most of nodular infiltration. A kidney invasion, only 23 percent have clinical features, 10% of the enlarged kidney, high blood pressure and blood urea nitrogen retention, the other still see Bangladesh in the kidney nephritis, nephrotic syndrome and renal Bangladesh Napster ended March with 410,000 have been reported. Biopsy found no tumor-infiltrating. But show show membranous nephropathy, a kidney immune complex in precipitation caused by the disease. Lymphoma ease when nephrotic syndrome also will be improved.

7), the nervous system involving the central nervous system symptoms caused by 100 to meet the 10 per cent of non-Hodgkin’s lymphoma, particularly diffuse the lymphocytes, and the small non-cleaved cell lymphoma. Retroperitoneal lymphoma can be nerve adjacent lymphatic intervertebral foramen violations of the spine and spinal cord, spinal cord compression have a levy, from paraplegia and urine retention, in Hodgkin’s disease incidence rate is about 3% to 7.5%. Paraplegia due to cancer can also be caused by violations of epidural. Violations of Mawei tumor, can cause lower limb Choutong, sacrococcygeal pain and numbness and walking difficulties, and so on. The brain is the progress of the invasion of diffuse large-cell non-Hodgkin’s lymphoma complications, most of meninges, the brain involved are rare. Ban Kuaizhuang tumor infiltration, can result in cranial nerve lesions, ophthalmoplegia and diplopia. Non-Hodgkin’s lymphoma see less involvement in the spinal cord.

8), other lymphoma can still infiltrating the pancreas, a malabsorption syndrome. Mediastinal lymphoma transferred to the pericardium, can cause localized tumor. Invasive breast, thyroid, oil gland, bladder, testicular and ovarian, and other corresponding symptom and cause are very rare.