Inhaled insulin or to increase the incidence of lung cancer
Posted by sunsu on November 16, 2008 in Diabetes
Insulin inhalation of such important but has not been fully recognized methods may increase the risk of lung cancer. They published on the treatment of inhaled insulin diabetes treatment in the article, McMahonandArky reported that the short-term animal experiments showed that the pulmonary and bronchial pulmonary small cell proliferation and no significant impact. This is not entirely correct. Published in the latest issue of “New England Journal of Medicine” on a short-term studies show that rats inhaled insulin could trigger an increase mitosis.
In response to the findings, Pfizer This manufacturing human insulin powder manufacturers plan to conduct a prospective study of up to 12 years, “the purpose was to compare received inhaled insulin therapy in patients and did not receive inhaled insulin therapy The mortality rate of lung cancer patients. “However, 20 years ago, the incidence of lung cancer depends on the ratio of smoking. So, 12 years and we expect to be a reliable result is not possible.
McMahon and Arky said, “When the combination of insulin in Type 1 insulin-like growth factor receptor on the time, it is only weak growth factor plays a role.” 1 at the same time, it also promote the role of mitosis, the role of yes yes By its own receptor-mediated, in the light receptor on the longer this role more obvious, like inhaled insulin is used as therapy. 4 lung in storage only 25 percent of the amount absorbed. 1 This will inevitably lead to a pulmonary and bronchial small organizations a high degree of aggregation of insulin. Bronchial epithelial cells of human studies have shown that insulin receptor activation, in essence, not enough to cause malignant transformation. However, these cells into malignant caused by other factors, the insulin receptor channel will promote the process of its deterioration.
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